Article
Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelodysplastic syndromes with normal cytogenetics.
Leukemia - 1 Sept 2009
Heinrichs S, Kulkarni R V, Bueso-Ramos C E, Levine R L, Loh M L, Li C, Neuberg D, Kornblau S M, Issa J-P, Gilliland D G, Garcia-Manero G, Kantarjian H M, Estey E H, Look A T
Abstract excerpt
Progress in the management of patients with myelodysplastic syndromes (MDS) has been hampered by the inability to detect cytogenetic abnormalities in 40-60% of cases. We prospectively analyzed matched pairs of bone marrow and buccal cell (normal) DNA samples from 51 MDS patients by single nucleotide polymorphism (SNP) arrays, and identified somatically acquired clonal genomic abnormalities in 21 patients (41%)....
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