Article
High concordance of genomic and cytogenetic aberrations between peripheral blood and bone marrow in myelodysplastic syndrome (MDS).
Leukemia - 1 Sept 2015
Mohamedali A M, Gäken J, Ahmed M, Malik F, Smith A E, Best S, Mian S, Gaymes T, Ireland R, Kulasekararaj A G, Mufti G J
Abstract excerpt
Bone marrow (BM) genetic abnormalities in myelodysplastic syndrome (MDS) have provided important biological and prognostic information; however, frequent BM sampling in older patients has been associated with significant morbidity. Utilizing single-nucleotide polymorphism array (SNP-A) and targeted gene sequencing (TGS) of 24 frequently mutated genes in MDS, we assessed the concordance of genetic abnormalities in...
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