Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lipophosphoglycan expression and virulence in ricin-resistant variants of Leishmania major.

Molecular and biochemical parasitology - 1 May 1990

Elhay M, Kelleher M, Bacic A, McConville M J, Tolson D L, Pearson T W, Handman E

Abstract excerpt

Lipophosphoglycan (LPG) of Leishmania is a polymorphic molecule comprising an alkylglycerol anchor, a conserved oligosaccharide core and a species-specific polymer of oligosaccharide repeats jointed by phosphodiester bonds. This molecule, together with the membrane polypeptide gp63, has been implicated as a parasite receptor for host macrophages. To examine the role of LPG in parasite infectivity glycosylation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Drug Resistance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Glycosphingolipids

Share to Mice, Inbred BALB C

Share to Virulence

Source

Identifiers

PMID: 2362605
DOI: 10.1016/0166-6851(90)90047-p

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lipophosphoglycan expression and virulence in ricin-resistant variants of Leishmania major.PMID 2362605Read ↗

Characterization of lipophosphoglycan from a ricin-resistant mutant of Leishmania major.Semantic proximity Read ↗

Leishmania LPG3 encodes a GRP94 homolog required for phosphoglycan synthesis implicated in parasite virulence but not viability.Semantic proximity Read ↗

Molecular variation in Leishmania.Semantic proximity Read ↗

Identification of a compensatory mutant (lpg2-REV) of Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates and its significance to virulence and immunization strategies.Semantic proximity Read ↗

Regulated expression of the <i>Leishmania major</i> surface virulence factor lipophosphoglycan using conditionally destabilized fusion proteinsSemantic proximity Read ↗

Characterization of Leishmania donovani variant clones using anti-lipophosphoglycan monoclonal antibodies.Semantic proximity Read ↗

Leishmania braziliensis: Strain-Specific Modulation of Phagosome MaturationSemantic proximity Read ↗

The role of GlcNAc-PI-de-N-acetylase gene by gene knockout through homologous recombination and its consequences on survival, growth and infectivity of Leishmania major in in vitro and in vivo conditions.Semantic proximity Read ↗

Characterization of a Leishmania mexicana mutant defective in synthesis of free and protein-linked GPI glycolipids.Semantic proximity Read ↗

Proteophosphoglycans of Leishmania mexicana. Molecular cloning and characterization of the Leishmania mexicana ppg2 gene encoding the proteophosphoglycans aPPG and pPPG2 that are secreted by amastigotes and promastigotes.Semantic proximity Read ↗

Isolation of virulence genes directing surface glycosyl-phosphatidylinositol synthesis by functional complementation of Leishmania.Semantic proximity Read ↗

Defective galactofuranose addition in lipophosphoglycan biosynthesis in a mutant of Leishmania donovani.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.