Article
The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts.
Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2003
Späth Gerald F, Garraway L A, Turco Salvatore J, Beverley Stephen M
Abstract excerpt
The abundant cell surface glycolipid lipophosphoglycan (LPG) was implicated in many steps of the Leishmania infectious cycle by biochemical tests. The presence of other abundant surface or secreted glycoconjugates sharing LPG domains, however, has led to uncertainty about the relative contribution of LPG in vivo. Here we used an Leishmania major lpg1- mutant, which lacks LPG alone and shows attenuated virulence,...
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