Obstacles on the microtubule reduce the processivity of Kinesin-1 in a minimal in vitro system and in cell extract.

Abstract excerpt

Inside cells, a multitude of molecular motors and other microtubule-associated proteins are expected to compete for binding to a limited number of binding sites available on microtubules. Little is known about how competition for binding sites affects the processivity of molecular motors and, therefore, cargo transport, organelle positioning, and microtubule organization, processes that all depend on the activity...

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