Article

A kinesin-1 variant reveals motor-induced microtubule damage in cells

2021-10-20

Abstract excerpt

Kinesins drive the transport of cellular cargoes as they walk along microtubule tracks, however, recent work has suggested that the physical act of kinesins walking along microtubules can stress the microtubule lattice. Here, we describe a kinesin-1 KIF5C mutant with an increased ability to generate defects in the microtubule lattice as compared to the wild-type motor. Expression of the mutant motor in cultured ce...

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Identifiers and source

Literature Corpus work: 762b44ec-66ad-5828-93e4-2581750ad3bd
DOI: 10.1101/2021.10.19.464974

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