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Article

Molecular Dynamics Simulation of Transmembrane Transport of Chloride Ions in Mutants of Channelrhodopsin.

Biomolecules - 10 Dec 2019

Zhang Wenying, Yang Ting, Zhou Shuangyan, Cheng Jie, Yuan Shuai, Lo Glenn V, Dou Yusheng

Abstract excerpt

Channelrhodopsins (ChRs) are light-gated transmembrane cation channels which are widely used for optogenetic technology. Replacing glutamate located at the central gate of the ion channel with positively charged amino acid residues will reverse ion selectivity and allow anion conduction. The structures and properties of the ion channel, the transport of chloride, and potential of mean force (PMF) of the chimera...

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Identifiers

PMID: 31835536
DOI: 10.3390/biom9120852
PMCID: PMC6995576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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