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Article

Influences of mutations on the electrostatic binding free energies of chloride ions in Escherichia coli ClC.

The journal of physical chemistry. B - 7 Jun 2012

Yu Tao, Wang Xiao-Qing, Sang Jian-Ping, Pan Chun-Xu, Zou Xian-Wu, Chen Tsung-Yu, Zou Xiaoqin

Abstract excerpt

Mutations in ClC channel proteins may cause serious functional changes and even diseases. The function of ClC proteins mainly manifests as Cl(-) transport, which is related to the binding free energies of chloride ions. Therefore, the influence of a mutation on ClC function can be studied by investigating the mutational effect on the binding free energies of chloride ions. The present study provides quantitative...

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Identifiers

PMID: 22612693
DOI: 10.1021/jp300430f
PMCID: PMC3411325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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