Article
High-throughput mutation screening using a single amplification condition.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009
Shi Lijia, Landers John E
Abstract excerpt
Numerous innovative and high-throughput techniques have been established to identify human disease genes. However, DNA sequencing of candidate genes still remains as a major limitation in the identification of causative mutations. Much of this limitation is due to the time and labor needed for the polymerase chain reaction (PCR) optimization and reaction setup. Toward this end, we have established a simplified...
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