Article
Single nucleotide polymorphisms of the tenomodulin gene (TNMD) in age-related macular degeneration.
Molecular vision - 1 Jan 2009
Tolppanen Anna-Maija, Nevalainen Tanja, Kolehmainen Marjukka, Seitsonen Sanna, Immonen Ilkka, Uusitupa Matti, Kaarniranta Kai, Pulkkinen Leena
Abstract excerpt
PURPOSE: Tenomodulin (TNMD) is located in the X-chromosome encoding a putative angiogenesis inhibitor which is expressed in retina. Associations of single nucleotide polymorphisms of TNMD with the prevalence of age-related macular degeneration (AMD) were examined. METHODS: Six markers covering 75% of the common sequence variation in the coding region of TNMD and 10 kb up- and downstream were genotyped in a sample...
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