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Article

Single nucleotide polymorphisms in MCP-1 and its receptor are associated with the risk of age related macular degeneration.

PloS one - 1 Jan 2012

Anand Akshay, Sharma Neel Kamal, Gupta Amod, Prabhakar Sudesh, Sharma Suresh Kumar, Singh Ramandeep, Gupta Pawan Kumar

Abstract excerpt

BACKGROUND: Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly population. We have shown previously that mice deficient in monocyte chemoattractant protein-1 (MCP1/CCL2) or its receptor (CCR2) develop the features of AMD in senescent mice, however, the human genetic evidence so far is contradictory. We hypothesized that any dysfunction in the CCL2 and its receptor result could...

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Identifiers

PMID: 23185481
DOI: 10.1371/journal.pone.0049905
PMCID: PMC3503775

Genes

CCL2
CCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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