Article
Tenomodulin variants, APOE and Alzheimer's disease in a Finnish case-control cohort.
Neurobiology of aging - 1 Mar 2011
Tolppanen Anna-Maija, Helisalmi Seppo, Hiltunen Mikko, Kolehmainen Marjukka, Schwab Ursula, Pirttilä Tuula, Pulkkinen Leena, Uusitupa Matti, Soininen Hilkka
Abstract excerpt
The tenomodulin gene (TNMD, locus Xq-22) encodes an angiogenesis inhibitor. It is an interesting candidate gene for Alzheimer's disease (AD), since it is expressed in brain, alterations in angiogenesis have been linked to AD and in our previous studies we have observed associations between TNMD and phenotypes, which are related to increased risk of AD. The common sequence variation in the TNMD was not associated...
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