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Article

Highly penetrant alleles in age-related macular degeneration.

Cold Spring Harbor perspectives in medicine - 6 Nov 2014

den Hollander Anneke I, de Jong Eiko K

Abstract excerpt

Age-related macular degeneration (AMD) is a complex disease caused by a combination of genetic and environmental factors. Genome-wide association studies have identified several common genetic variants associated with AMD, which together account for 15%-65% of the heritability of AMD. Multiple hypotheses to clarify the unexplained portion of genetic variance have been proposed, such as gene-gene interactions,...

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Identifiers

PMID: 25377141
DOI: 10.1101/cshperspect.a017202
PMCID: PMC4355254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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