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Article

Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study.

Obesity (Silver Spring, Md.) - 1 May 2007

Tolppanen Anna-Maija, Pulkkinen Leena, Kolehmainen Marjukka, Schwab Ursula, Lindström Jaana, Tuomilehto Jaakko, Uusitupa Matti

Abstract excerpt

We recently showed that long-term weight reduction changes the gene expression profile of adipose tissue in overweight individuals with impaired glucose tolerance (IGT). One of the responding genes was X-chromosomal tenomodulin (TNMD), a putative angiogenesis inhibitor. Our aim was to study the associations of individual single nucleotide polymorphisms and haplotypes with adiposity, glucose metabolism, and the...

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Source

Identifiers

PMID: 17495183
DOI: 10.1038/oby.2007.613

Genes

TNMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study.PMID 17495183Read ↗

The genetic variation of the tenomodulin gene (TNMD) is associated with serum levels of systemic immune mediators--the Finnish Diabetes Prevention Study.Semantic proximity Read ↗

The genetic variation in the tenomodulin gene is associated with serum total and LDL cholesterol in a body size-dependent manner.Semantic proximity Read ↗

Tenomodulin gene and obesity-related phenotypes.Semantic proximity Read ↗

Tenomodulin Is Highly Expressed in Adipose Tissue, Increased in Obesity, and Down-Regulated during Diet-Induced Weight LossSemantic proximity Read ↗

Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansionSemantic proximity Read ↗

Tenomodulin variants, APOE and Alzheimer's disease in a Finnish case-control cohort.Semantic proximity Read ↗

Single nucleotide polymorphisms of the tenomodulin gene (TNMD) in age-related macular degeneration.Semantic proximity Read ↗

Genetically proxied growth differentiation factor 15 levels and body mass indexSemantic proximity Read ↗

Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans.Semantic proximity Read ↗

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