Article
The genetic variation of the tenomodulin gene (TNMD) is associated with serum levels of systemic immune mediators--the Finnish Diabetes Prevention Study.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jul 2008
Tolppanen Anna-Maija, Pulkkinen Leena, Herder Christian, Koenig Wolfgang, Kolehmainen Marjukka, Lindström Jaana, Tuomilehto Jaakko, Uusitupa Matti
Abstract excerpt
PURPOSE: We have reported that the genetic variation of the tenomodulin gene (TNMD) is associated with the risk of type 2 diabetes (T2DM), central obesity, and impaired glucose metabolism and the TNMD mRNA levels correlate with serum and mRNA levels of inflammatory markers. Our objective was to investigate the genetic associations of the single nucleotide polymorphisms of the TNMD gene with the serum levels of...
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