Article
Cutting edge: genetic characterization of IFN-producing killer dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 2009
Guimont-Desrochers Fanny, Cappello Zachary John, Chagnon Miguel, McDuffie Marcia, Lesage Sylvie
Abstract excerpt
The combined phenotypic expression of CD11c(low)B220(+)CD122(+)DX5(+) has been used to define a novel cell type termed IFN-producing killer dendritic cells (IKDC). IKDC readily produce IFN-gamma and demonstrate spontaneous cytotoxic activity toward tumors, suggesting that a modulation of IKDC number may be beneficial in cancer treatment. We examined various mouse strains and found that IKDC number was highly...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.