Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia.

International journal of cancer - 1 Jan 2016

Johansson Patricia, Bergmann Anke, Rahmann Sven, Wohlers Inken, Scholtysik René, Przekopowitz Martina, Seifert Marc, Tschurtschenthaler Gertraud, Webersinke Gerald, Jäger Ulrich, Siebert Reiner, Klein-Hitpass Ludger, Dührsen Ulrich, Dürig Jan, Küppers Ralf

Abstract excerpt

The pathogenesis of T-cell large granular lymphocytic leukemia (T-LGL) is poorly understood, as STAT3 mutations are the only known frequent genetic lesions. Here, we identified non-synonymous alterations in the TNFAIP3 tumor suppressor gene in 3 of 39 T-LGL. In two cases these were somatic mutations, in one case the somatic origin was likely. A further case harbored a SNP that is a known risk allele for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cohort Studies
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Leukemia, Large Granular Lymphocytic

Share to Nuclear Proteins

Share to STAT3 Transcription Factor

Share to Tumor Necrosis Factor alpha-Induced Protein 3

Source

Identifiers

PMID: 26199174
DOI: 10.1002/ijc.29697

Genes

TNFAIP3
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia.PMID 26199174Read ↗

Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activationSemantic proximity Read ↗

The spectrum of somatic mutations in large granular lymphocyte leukemia, rheumatoid arthritis, and Felty's syndrome.Semantic proximity Read ↗

Genetic Mutations Associated With TNFAIP3 (A20) Haploinsufficiency and Their Impact on Inflammatory Diseases.Semantic proximity Read ↗

Germline and somatic genetic variations of TNFAIP3 in lymphoma complicating primary Sjogren's syndrome.Semantic proximity Read ↗

Mutation analysis of the TNFAIP3 (A20) tumor suppressor gene in CLL.Semantic proximity Read ↗

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus.Semantic proximity Read ↗

TNFAIP3 mutation is an independent poor overall survival factor for patients with T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Inherited <i>STAT3</i> mutation mediates familial autoimmune disease, leukemogenesis, and responses to immunomodulatorSemantic proximity Read ↗

TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma.Semantic proximity Read ↗

Somatic STAT3 mutations in large granular lymphocytic leukemia.Semantic proximity Read ↗

Haploinsufficiency of A20 caused by a novel pathogenic missense variant of TNFAIP3 and successfully treated with anti-TNF and immunosuppressive therapiesSemantic proximity Read ↗

Novel loss-of-function mutations in TNFAIP3 gene in patients with lupus nephritisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.