Article
Lasp1 misexpression influences chondrocyte differentiation in the vertebral column.
The International journal of developmental biology - 1 Jan 2009
Hermann-Kleiter Natascha, Ghaffari-Tabrizi Nassim, Blumer Michael J F, Schwarzer Christoph, Mazur Magdalena A, Artner Isabella
Abstract excerpt
The mouse mutant wavy tail Tg(Col1a1-lacZ)304ng was created through transgene insertion and exhibits defects of the vertebral column. Homozygous mutant animals have compressed tail vertebrae and wedge-shaped intervertebral discs, resulting in a meandering tail. Delayed closure of lumbar neural arches and lack of processus spinosi have been observed; these defects become most prominent during the transition from...
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