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Article

Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes.

Journal of cell science - 1 Mar 2005

Bengtsson Therese, Aszodi Attila, Nicolae Claudia, Hunziker Ernst B, Lundgren-Akerlund Evy, Fässler Reinhard

Abstract excerpt

Integrin alpha10beta1 is a collagen-binding integrin expressed on chondrocytes. In order to unravel the role of the alpha10 integrin during development, we generated mice carrying a constitutive deletion of the alpha10 integrin gene. The mutant mice had a normal lifespan and were fertile but developed a growth retardation of the long bones. Analysis of the skeleton revealed defects in the growth plate after birth...

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Source

Identifiers

PMID: 15713743
DOI: 10.1242/jcs.01678

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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