Article
BAC constructs in transgenic reporter mouse lines control efficient and specific LacZ expression in hypertrophic chondrocytes under the complete Col10a1 promoter.
Histochemistry and cell biology - 1 Feb 2007
Gebhard Sonja, Hattori Takako, Bauer Eva, Bösl Michael R, Schlund Britta, Pöschl Ernst, Adam Nadia, de Crombrugghe Benoit, von der Mark Klaus
Abstract excerpt
During endochondral ossification hypertrophic chondrocytes in the growth plate of fetal long bones, ribs and vertebrae play a key role in preparing growth plate cartilage for replacement by bone. In order to establish a reporter gene mouse to facilitate functional analysis of genes expressed in hypertrophic chondrocytes in this process, Col10a1- BAC reporter gene mouse lines were established expressing LacZ...
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