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Article

Characterization of a novel Lbx1 mouse loss of function strain.

Differentiation; research in biological diversity - 1 Jan 2000

Decourtye Lyvianne, McCallum-Loudeac Jeremy A, Zellhuber-McMillan Sylvia, Young Emma, Sircombe Kathleen J, Wilson Megan J

Abstract excerpt

Adolescent Idiopathic Scoliosis (AIS) is the most common type of spine deformity affecting 2-3% of the population worldwide. The etiology of this disease is still poorly understood. Several GWAS studies have identified single nucleotide polymorphisms (SNPs) located near the gene LBX1 that is significantly correlated with AIS risk. LBX1 is a transcription factor with roles in myocyte precursor migration, cardiac...

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PMID: 34906895
DOI: 10.1016/j.diff.2021.12.001

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