Transcription mapping and expression analysis of candidate genes in the vicinity of the mouse Loop-tail mutation.

Abstract excerpt

Loop-tail (Lp) is a semidominant mutation that maps to the distal portion of mouse Chromosome (Chr) 1 and is an established model for neural tube defects (NTDs). Homozygous embryos exhibit an open neural tube from the caudal midbrain to the tip of the tail that results from over-differentiation of the floor plate. To facilitate the positional cloning of the Lp gene, both cDNA selection and assignment of...

Topics

• Animals
• Blotting, Northern
• Chromosome Mapping
• Disease Models, Animal
• Embryo, Mammalian
• Gene Expression
• Gene Expression Regulation, Developmental
• Humans
• Male
• Mice
• Mutation