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Article

Endogenous Betaglycan Is Essential for High-Potency Inhibin Antagonism in Gonadotropes

17 Apr 2009

Abstract excerpt

Inhibins are endocrine hormones that regulate gametogenesis and reproduction through a negative feedback loop with FSH. Inhibin action involves antagonism of signaling by activin or other TGFbeta family ligands. In transfection assays, antagonism by inhibin can be potentiated by betaglycan, a coreceptor for selected TGFbeta family ligands. We tested whether betaglycan is an obligate inhibin coreceptor through...

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PMID: 19372236
DOI: 10.1210/me.2009-0021

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Endogenous Betaglycan Is Essential for High-Potency Inhibin Antagonism in GonadotropesPMID 19372236Read ↗

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