Article
β-catenin stabilization in gonadotropes impairs FSH synthesis in male mice in vivo.
Endocrinology - 1 Jan 2015
Boerboom Derek, Kumar Vikas, Boyer Alexandre, Wang Ying, Lambrot Romain, Zhou Xiang, Rico Charlène, Boehm Ulrich, Paquet Marilène, Céleste Christophe, Kimmins Sarah, Bernard Daniel J
Abstract excerpt
Although classically considered a WNT signaling intermediary, β-catenin (CTNNB1) can also mediate GnRH induction of gonadotropin β-subunit (Fshb and Lhb) transcription in the murine gonadotrope-like cell line LβT2. Here, we assessed CTNNB1's role in gonadotropin synthesis in vivo. We used a Cre/lox approach to introduce both gain- and loss-of-function mutations in the murine Ctnnb1 gene in gonadotrope cells....
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