Article
Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites.
The Journal of cell biology - 1 Feb 1994
López-Casillas F, Payne H M, Andres J L, Massagué J
Abstract excerpt
Betaglycan, also known as the TGF-beta type III receptor, is a membrane-anchored proteoglycan that presents TGF-beta to the type II signaling receptor, a transmembrane serine/threonine kinase. The betaglycan extracellular region, which can be shed by cells into the medium, contains a NH2-terminal...
Topics
- Animals
- Cell Membrane
- Glycosaminoglycans
- Humans
- Ligands
- Membrane Proteins
- Mucoproteins
- Mutation
- Proteoglycans
- Rats
- Receptors, Transforming Growth Factor beta
- Signal Transduction
- Solubility
- Transforming Growth Factor beta
- Uromodulin