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Article

Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites.

The Journal of cell biology - 1 Feb 1994

López-Casillas F, Payne H M, Andres J L, Massagué J

Abstract excerpt

Betaglycan, also known as the TGF-beta type III receptor, is a membrane-anchored proteoglycan that presents TGF-beta to the type II signaling receptor, a transmembrane serine/threonine kinase. The betaglycan extracellular region, which can be shed by cells into the medium, contains a NH2-terminal domain related to endoglin and a COOH-terminal domain related to uromodulin, sperm receptors Zp2 and 3, and pancreatic...

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Identifiers

PMID: 8106553
DOI: 10.1083/jcb.124.4.557
PMCID: PMC2119924

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites.PMID 8106553Read ↗

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The search for glycan function: fucosylation of the TGF-beta1 receptor is required for receptor activation.Semantic proximity Read ↗

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The unglycosylated extracellular domain of type-II receptor for transforming growth factor-beta. A novel assay for characterizing ligand affinity and specificity.Semantic proximity Read ↗

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