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Article

Synergistic induction of follicle-stimulating hormone beta-subunit gene expression by gonadal steroid hormone receptors and Smad proteins.

Endocrinology - 1 Mar 2008

Thackray Varykina G, Mellon Pamela L

Abstract excerpt

LH and FSH play crucial roles in mammalian reproduction by mediating steroidogenesis and gametogenesis. Gonadal steroid hormones influence gonadotropin production via feedback to the hypothalamus and pituitary. We previously demonstrated that progesterone and testosterone can stimulate expression of the FSH beta-subunit gene in immortalized gonadotrope-derived LbetaT2 cells. Herein, we investigate how these...

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Identifiers

PMID: 18079204
DOI: 10.1210/en.2007-1498
PMCID: PMC2275352

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Synergistic induction of follicle-stimulating hormone beta-subunit gene expression by gonadal steroid hormone receptors and Smad proteins.PMID 18079204Read ↗

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