Article
Constitutive expression of cat-86 associated with a change in the transcription start point.
Gene - 30 Aug 1991
Ambulos N P, Kim U J, Rogers E J, Lovett P S
Abstract excerpt
The translational attenuation regulatory model suggests a mechanism that can explain the induction of cat-86 by chloramphenicol (Cm). In this model, Cm serves to stall a ribosome at a specific site in a leader region of cat-86 transcripts. The stalled ribosome is thought to destabilize a downstream region of RNA secondary structure that normally sequesters the cat-86 ribosome-binding site (RBS-3). Three mutations...
Topics
- Amino Acid Sequence
- Bacillus subtilis
- Base Sequence
- Chloramphenicol
- Chloramphenicol O-Acetyltransferase
- Chloramphenicol Resistance
- Codon
- Gene Expression Regulation, Bacterial
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation