A gratuitous inducer of cat-86, amicetin, inhibits bacterial peptidyl transferase.

doi:10.1128/jb.177.12.3616-3618.1995

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Article

A gratuitous inducer of cat-86, amicetin, inhibits bacterial peptidyl transferase.

Journal of bacteriology - 1 Jun 1995

Gu Z, Lovett P S

Abstract excerpt

Expression of the chloramphenicol resistance gene cat-86 is regulated by translation attenuation. Among the three ribosomally targeted antibiotics that can induce the gene, only amicetin has an unknown mode of action. Here we demonstrate that the nucleoside antibiotic amicetin is an inhibitor of...

Topics

Anti-Bacterial Agents
Bacillus subtilis
Chloramphenicol Resistance
Gene Expression Regulation, Bacterial
Mutation
Peptidyl Transferases
Pyrimidine Nucleosides
Ribosomes

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