Article
Micronucleus occurrence related to base excision repair gene polymorphisms in Chinese workers occupationally exposed to vinyl chloride monomer.
Journal of occupational and environmental medicine - 1 May 2009
Wen-Bin Miao, Wei Wang, Yu-Lan Qiu, Fang Ji, Zhao-Lin Xia
Abstract excerpt
OBJECTIVE: To evaluate whether base excision repair gene polymorphisms contributed to susceptibility of chromosomal damage induced by vinyl chloride monomer (VCM). METHODS: Cytokinesis block micronucleus test was performed on 185 VCM-exposed workers to detect chromosomal damage in peripheral lymphocytes. The PCR-restriction fragment length polymorphism technique was applied to detect polymorphisms of TDG, PARP1,...
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