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Article

Polymorphisms of DNA repair gene XPD and DNA damage of workers exposed to vinylchloride monomer.

International journal of hygiene and environmental health - 1 Jan 2005

Zhu Shoumin, Wang Aihong, Xia Zhaolin

Abstract excerpt

Vinyl chloride monomer (VCM) is a human carcinogen. However, the exact mechanism of carcinogenesis remains unclear. 2-Chloroethylene oxide (CEO) and 2-chloroacetaldehyde (CAA), the metabolic intermediates of VCM, induce DNA damage which is mainly repaired by the nucleotide excision repair (NER) pathway. The XPD gene product and the related XPB protein are DNA helicases that are involved in transcription and NER....

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Identifiers

PMID: 16217922
DOI: 10.1016/j.ijheh.2005.05.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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