Article
Genetic polymorphisms in metabolizing enzymes and susceptibility of chromosomal damage induced by vinyl chloride monomer in a Chinese worker population.
Journal of occupational and environmental medicine - 1 Feb 2010
Wang Wei, Qiu Yu-lan, Ji Fang, Liu Jing, Wu Fen, Miao Wen-bin, Li Yongliang, Brandt-Rauf Paul W, Xia Zhao-lin
Abstract excerpt
OBJECTIVE: To evaluate whether polymorphisms in metabolizing enzymes contributed to susceptibility of chromosomal damage induced by vinyl chloride monomer (VCM). METHODS: Cytokinesis block micronucleus test was performed on 185 VCM-exposed workers and 41 control subjects to detect chromosomal damage in peripheral lymphocytes. The polymerase chain reaction and restriction fragment length polymorphism technique was...
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