Interallelic complementation among DER/flb alleles: implications for the mechanism of signal transduction by receptor-tyrosine kinases.

doi:10.1093/genetics/129.1.191

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Article

Interallelic complementation among DER/flb alleles: implications for the mechanism of signal transduction by receptor-tyrosine kinases.

Genetics - 1 Sept 1991

Raz E, Schejter E D, Shilo B Z

Abstract excerpt

The large number of available embryonic lethal alleles in the Drosophila EGF receptor homolog (DER)/faint little ball locus allowed us to test the possibility of positive or negative interactions among different DER alleles. These interactions were monitored by examining the embryonic cuticular phenotypes of different heteroallelic combinations. Several positive interactions were identified, while negative...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
DNA Mutational Analysis
Drosophila
ErbB Receptors
Ethyl Methanesulfonate
Genes, Lethal
Genetic Complementation Test
Macromolecular Substances

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Genetic

Molecular Sequence Data

Mutation

Phenotype

Phosphorylation

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 1936959
DOI: 10.1093/genetics/129.1.191
PMCID: PMC1204566

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1936959-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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