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Article

Molecular basis of intracistronic complementation in the Passover locus of Drosophila.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 1995

Krishnan S N, Frei E, Schalet A P, Wyman R J

Abstract excerpt

The only demonstrated mechanism for intracistronic genetic complementation requires physical interaction of protein subunits to create a functional molecule. We demonstrate another and perhaps quite general mechanism utilizing proteins with unique and shared domains. The Drosophila neural mutant Passover (Pas) disrupts specific synaptic connections. Alleles of a lethal complementation group exhibit a complex...

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Identifiers

PMID: 7892218
DOI: 10.1073/pnas.92.6.2021
PMCID: PMC42415

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