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Article

LKB1 catalytic activity contributes to estrogen receptor alpha signaling.

Molecular biology of the cell - 1 Jun 2009

Nath-Sain Suchita, Marignani Paola A

Abstract excerpt

The tumor suppressor serine-threonine kinase LKB1 is mutated in Peutz-Jeghers syndrome (PJS) and in epithelial cancers, including hormone-sensitive organs such as breast, ovaries, testes, and prostate. Clinical studies in breast cancer patients show low LKB1 expression is related to poor prognosis, whereas in PJS, the risk of breast cancer is similar to the risk from germline mutations in breast cancer (BRCA)...

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Source

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Identifiers

PMID: 19369417
DOI: 10.1091/mbc.e08-11-1138
PMCID: PMC2688557

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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