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Article

Uncoupling protein 2 Ala55Val polymorphism is associated with a higher acute insulin response to glucose.

Metabolism: clinical and experimental - 1 Jun 2009

Willig Amanda L, Casazza Krista R, Divers Jasmin, Bigham Abigail W, Gower Barbara A, Hunter Gary R, Fernandez Jose R

Abstract excerpt

Recent evidence suggests that mitochondrial uncoupling protein 2 (UCP2) in pancreatic beta-cells plays a crucial role in insulin production and secretion. We hypothesized that 2 UCP2 polymorphisms, a -55C/T (Ala55Val) substitution in exon 4 and an exon 8 insertion, would alter the acute insulin response to glucose (AIRg). Subjects were 155 African American (AA) and European American (EA) women. Body composition...

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Source

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Identifiers

PMID: 19368944
DOI: 10.1016/j.metabol.2009.02.016
PMCID: PMC2704067

Genes

UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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