Article
The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes.
Diabetes - 1 Jul 2004
D'Adamo Monica, Perego Lucia, Cardellini Marina, Marini Maria Adelaide, Frontoni Simona, Andreozzi Francesco, Sciacqua Angela, Lauro Davide, Sbraccia Paolo, Federici Massimo, Paganelli Michele, Pontiroli Antonio E, Lauro Renato, Perticone Francesco, Folli Franco, Sesti Giorgio
Abstract excerpt
Uncoupling protein (UCP)-2 is a member of the mitochondrial inner membrane carriers that uncouple pro-ton entry in the mitochondrial matrix from ATP synthesis. The -866G/A polymorphism in the UCP2 gene, which enhances its transcriptional activity, was associated with enhanced risk for type 2 diabetes in obese subjects. We addressed the question of whether the -866G/A polymorphism contributes to variation in...
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