Newborn- and adult-derived brain microvascular endothelial cells show age-related differences in phenotype and glutamate-evoked protease release.

doi:10.1038/jcbfm.2009.39

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Article

Newborn- and adult-derived brain microvascular endothelial cells show age-related differences in phenotype and glutamate-evoked protease release.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Jun 2009

Legros Hélène, Launay Séverine, Roussel Benoit Denis, Marcou-Labarre Aurélie, Calbo Sébastien, Catteau Julie, Leroux Philippe, Boyer Olivier, Ali Carine, Marret Stéphane, Vivien Denis, Laudenbach Vincent

Abstract excerpt

Few data are available on the involvement of brain microvascular endothelial cells (BMECs) in excitotoxic neonatal brain lesions. Therefore, we developed an original approach for investigating mouse-derived BMECs in vitro. We hypothesized that newborn and adult BMEC cultures would show age-related differences in phenotype and sensitivity to glutamate. Expression of the monocarboxylate transporter, MCT1, was...

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PMID: 19367295
DOI: 10.1038/jcbfm.2009.39

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