Article
Overexpression of vascular endothelial growth factor in the germinal matrix induces neurovascular proteases and intraventricular hemorrhage.
Science translational medicine - 10 Jul 2013
Yang Dianer, Baumann Jessica M, Sun Yu-Yo, Tang Mianzhi, Dunn Richard Scott, Akeson Ann L, Kernie Steven G, Kallapur Suhas, Lindquist Diana M, Huang Eric J, Potter Stanley Steven, Liang Hung-Chi, Kuan Chia-Yi
Abstract excerpt
Intracranial hemorrhage in preterm neonates may result in neonatal mortality and functional disabilities, but its pathogenic mechanisms are poorly defined and better therapies are needed. We used a tetracycline-regulated transgenic system to test whether the induction of vascular endothelial growth factor (VEGF) in the germinal matrix leads to intracranial hemorrhage. This genetic strategy initially induced a...
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