Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Age-dependent neonatal intracerebral hemorrhage in plasminogen activator inhibitor 1 knockout mice.

Journal of neuropathology and experimental neurology - 1 May 2014

Leroux Philippe, Omouendze Priscilla L, Roy Vincent, Dourmap Nathalie, Gonzalez Bruno J, Brasse-Lagnel Carole, Carmeliet Peter, Leroux-Nicollet Isabelle, Marret Stéphane

Abstract excerpt

Intracerebral-intraventricular hemorrhages (ICH/IVH) in very preterm neonates are responsible for high mortality and subsequent disabilities. In humans, tissue plasminogen activator (t-PA) initiates fibrinolysis and activates endoluminal-endothelial receptors; dysfunction of the t-PA inhibitor (PAI-1) results in recurrent hemorrhages. We used PAI-1 knockout (PAI-1) mice to examine the role of t-PA in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Animals, Newborn

Share to Aprotinin

Share to Cerebral Hemorrhage

Share to Mice, 129 Strain

Share to Mice, Knockout

Share to Motor Activity

Source

Identifiers

PMID: 24709679
DOI: 10.1097/NEN.0000000000000062

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age-dependent neonatal intracerebral hemorrhage in plasminogen activator inhibitor 1 knockout mice.PMID 24709679Read ↗

Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice.Semantic proximity Read ↗

Cerebral infarctions in the fetus and neonate: maternal-placental-fetal considerations.Semantic proximity Read ↗

Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly.Semantic proximity Read ↗

Age-associated changes in endothelial transcriptome and chromatin landscape correlate with elevated risk of hemorrhageSemantic proximity Read ↗

Development and validation of prechiasmatic mouse model of subarachnoid hemorrhage to measure long-term neurobehavioral impairmentSemantic proximity Read ↗

A1 adenosine receptors mediate hypoxia-induced ventriculomegaly.Semantic proximity Read ↗

Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator.Semantic proximity Read ↗

Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1-related stroke.Semantic proximity Read ↗

Overexpression of vascular endothelial growth factor in the germinal matrix induces neurovascular proteases and intraventricular hemorrhage.Semantic proximity Read ↗

Perinatal Micro-Bleeds and Neuroinflammation in E19 Rat Fetuses Exposed to Utero-Placental IschemiaSemantic proximity Read ↗

Gene-environment interactions in severe intraventricular hemorrhage of preterm neonates.Semantic proximity Read ↗

Age-Dependent Lethality in Novel Transgenic Mouse Models of Central Nervous System Arteriovenous MalformationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.