Article
Vulnerability of white matter towards antenatal hypoxia is linked to a species-dependent regulation of glutamate receptor subunits.
Proceedings of the National Academy of Sciences of the United States of America - 28 Oct 2008
Fontaine Romain H, Olivier Paul, Massonneau Véronique, Leroux Philippe, Degos Vincent, Lebon Sophie, El Ghouzzi Vincent, Lelièvre Vincent, Gressens Pierre, Baud Olivier
Abstract excerpt
White-matter damage is a leading cause of neurological handicap. Although hypoxia-ischemia and excitotoxicity are major pathogenic factors, a role for genetic influences was suggested recently. Thus, protracted gestational hypoxia was associated with white-matter damage (WMD) in rat pups but not in mouse pups. Indeed, microglial activation and vessel-wall density on postnatal days (P)1 and P10 were found...
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