Article
Cortical consequences of in vivo blockade of monocarboxylate transport during brain development in mice.
Pediatric research - 1 Jan 2007
Adle-Biassette Homa, Olivier Paul, Verney Catherine, Fontaine Romain H, Evrard Phillippe, Hénin Dominique, Massias Laurent, Gressens Pierre, Baud Olivier
Abstract excerpt
In addition to glucose, monocarboxylates including lactate represent a major source of energy for the developing brain and appears to be crucial in the pathogenesis and recovery after brain damage. We hypothesized a role of monocarboxylates transport in the energy supply of neurons of the immature cerebral cortex. The effects of the blockade of monocarboxylates transport in vivo on the cortical development was...
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