Plasmacytoid dendritic cells accumulate in spleens from chronically HIV-infected patients but barely participate in interferon-alpha expression.

doi:10.1182/blood-2008-07-170803

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Article

Plasmacytoid dendritic cells accumulate in spleens from chronically HIV-infected patients but barely participate in interferon-alpha expression.

Blood - 11 Jun 2009

Nascimbeni Michelina, Perié Leïla, Chorro Laurent, Diocou Seckou, Kreitmann Louis, Louis Stéphanie, Garderet Laurent, Fabiani Bettina, Berger Anne, Schmitz Jürgen, Marie Jean-Pierre, Molina Thierry Jo, Pacanowski Jérôme, Viard Jean-Paul, Oksenhendler Eric, Beq Stéphanie, Abehsira-Amar Orly, Cheynier Rémi, Hosmalin Anne

Abstract excerpt

We characterized the localization, phenotype, and some functions of plasmacytoid dendritic cells (pDCs) in the human spleen. pDCs were localized in the marginal zone and the periarteriolar region. Some were also found in the red pulp. pDCs were immature by phenotypic labeling, consistently with their capacity to internalize Dextran in a functional assay. In spleens from HIV-infected patients with thrombocytopenic...

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PMID: 19366987
DOI: 10.1182/blood-2008-07-170803

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