Article
Infection frequency of dendritic cells and CD4+ T lymphocytes in spleens of human immunodeficiency virus-positive patients.
Journal of virology - 1 Aug 1995
McIlroy D, Autran B, Cheynier R, Wain-Hobson S, Clauvel J P, Oksenhendler E, Debré P, Hosmalin A
Abstract excerpt
Dendritic cells (DC) are specialized antigen-presenting leukocytes that are responsible for the activation of naive as well as memory T lymphocytes. If infected by human immunodeficiency virus (HIV), DC may transfer virus to CD4+ lymphocytes. However, the question of whether DC are infected in vivo is controversial. As HIV infection is more active in secondary lymphoid organs than in blood, infection of splenic...
Topics
- CD4-Positive T-Lymphocytes
- DNA, Viral
- Dendritic Cells
- HIV
- HIV Seropositivity
- Humans
- Lymphocyte Culture Test, Mixed
- Macrophages
- Phenotype
- Polymerase Chain Reaction
- Spleen