Article
An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice.
Nature genetics - 1 May 2009
Lewis Morag A, Quint Elizabeth, Glazier Anne M, Fuchs Helmut, De Angelis Martin Hrabé, Langford Cordelia, van Dongen Stijn, Abreu-Goodger Cei, Piipari Matias, Redshaw Nick, Dalmay Tamas, Moreno-Pelayo Miguel Angel, Enright Anton J, Steel Karen P
Abstract excerpt
Progressive hearing loss is common in the human population, but little is known about the molecular basis. We report a new N-ethyl-N-nitrosurea (ENU)-induced mouse mutant, diminuendo, with a single base change in the seed region of Mirn96. Heterozygotes show progressive loss of hearing and hair cell anomalies, whereas homozygotes have no cochlear responses. Most microRNAs are believed to downregulate target genes...
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