Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment.

Nature protocols - 1 Jan 2010

Hardisty-Hughes Rachel E, Parker Andrew, Brown Steve D M

Abstract excerpt

We describe a protocol for the production of mice carrying N-ethyl-N-nitrosourea (ENU) mutations and their screening for auditory and vestibular phenotypes. In comparison with the procedures describing individual phenotyping tests, this protocol integrates a set of tests for the comprehensive determination of the causes of hearing loss. It comprises a primary screen of relatively simple auditory and vestibular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Behavior, Animal
Share to Breeding
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ear, Inner

Share to Ethylnitrosourea

Share to Genetic Testing

Share to Hearing Loss

Source

Identifiers

PMID: 20057387
DOI: 10.1038/nprot.2009.204

Genes

ABR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment.PMID 20057387Read ↗

Mouse models for human deafness: current tools for new fashions.Semantic proximity Read ↗

Identification of 17 hearing impaired mouse strains in the TMGC ENU-mutagenesis screen.Semantic proximity Read ↗

Identification and characterisation of new mouse models for hearing lossSemantic proximity Read ↗

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.Semantic proximity Read ↗

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.Semantic proximity Read ↗

Genetics of peripheral vestibular dysfunction: lessons from mutant mouse strains.Semantic proximity Read ↗

Inherited hearing defects in mice.Semantic proximity Read ↗

Analysis of the mouse mutant Cloth-ears shows a role for the voltage-gated sodium channel Scn8a in peripheral neural hearing loss.Semantic proximity Read ↗

An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice.Semantic proximity Read ↗

Adeno-associated viral vector administration to the inner ear and phenotype evaluation in a mouse model of hearing loss.Semantic proximity Read ↗

A Myo7a mutation cosegregates with stereocilia defects and low-frequency hearing impairment.Semantic proximity Read ↗

Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.