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Article

Genome-wide phenotypic RNAi screen in the Drosophila wing: global parameters.

G3 (Bethesda, Md.) - 8 Dec 2021

López-Varea Ana, Ostalé Cristina M, Vega-Cuesta Patricia, Ruiz-Gómez Ana, Organista María F, Martín Mercedes, Hevia Covadonga F, Molnar Cristina, de Celis Jesús, Culi Joaquim, Esteban Nuria, de Celis Jose F

Abstract excerpt

We have screened a collection of UAS-RNAi lines targeting 10,920 Drosophila protein-coding genes for phenotypes in the adult wing. We identified 3653 genes (33%) whose knockdown causes either larval/pupal lethality or a mutant phenotype affecting the formation of a normal wing. The most frequent phenotypes consist of changes in wing size, vein differentiation, and patterning, defects in the wing margin and in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34599819
DOI: 10.1093/g3journal/jkab351
PMCID: PMC8962446

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