Article
Human genomics. The human transcriptome across tissues and individuals.
Science (New York, N.Y.) - 8 May 2015
Melé Marta, Ferreira Pedro G, Reverter Ferran, DeLuca David S, Monlong Jean, Sammeth Michael, Young Taylor R, Goldmann Jakob M, Pervouchine Dmitri D, Sullivan Timothy J, Johnson Rory, Segrè Ayellet V, Djebali Sarah, Niarchou Anastasia, Wright Fred A, Lappalainen Tuuli, Calvo Miquel, Getz Gad, Dermitzakis Emmanouil T, Ardlie Kristin G, Guigó Roderic
Abstract excerpt
Transcriptional regulation and posttranscriptional processing underlie many cellular and organismal phenotypes. We used RNA sequence data generated by Genotype-Tissue Expression (GTEx) project to investigate the patterns of transcriptome variation across individuals and tissues. Tissues exhibit characteristic transcriptional signatures that show stability in postmortem samples. These signatures are dominated by a...
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