Article
Fcab-HER2 Interaction: a Ménage à Trois. Lessons from X-Ray and Solution Studies.
Structure (London, England : 1993) - 6 Jun 2017
Lobner Elisabeth, Humm Anne-Sophie, Göritzer Kathrin, Mlynek Georg, Puchinger Martin G, Hasenhindl Christoph, Rüker Florian, Traxlmayr Michael W, Djinović-Carugo Kristina, Obinger Christian
Abstract excerpt
The crystallizable fragment (Fc) of the immunoglobulin class G (IgG) is an attractive scaffold for the design of novel therapeutics. Upon engineering the C-terminal loops in the CH3 domains, Fcabs (Fc domain with antigen-binding sites) can be designed. We present the first crystal structures of Fcabs, i.e., of the HER2-binding clone H10-03-6 having the AB and EF loop engineered and the stabilized version STAB19...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.