Article
Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages.
The Journal of biological chemistry - 20 Dec 2002
Kunjathoor Vidya V, Febbraio Maria, Podrez Eugene A, Moore Kathryn J, Andersson Lorna, Koehn Stephanie, Rhee Jeongmi S, Silverstein Roy, Hoff Henry F, Freeman Mason W
Abstract excerpt
Modification of low density lipoprotein (LDL) can result in the avid uptake of these lipoproteins via a family of macrophage transmembrane proteins referred to as scavenger receptors (SRs). The genetic inactivation of either of two SR family members, SR-A or CD36, has been shown previously to reduce oxidized LDL uptake in vitro and atherosclerotic lesions in mice. Several other SRs are reported to bind modified...
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