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Article

Mouse CD36 Has Opposite Effects on LDL and Oxidized LDL Metabolism In Vivo

24 Apr 2008

Abstract excerpt

OBJECTIVE: The cluster of differentiation-36 (CD36) is a multifunctional protein which is recognized for its in vitro ability to take up oxidized low-density lipoproteins (oxLDL) in macrophages and is therefore considered atherogenic. It also binds LDL. Our objective was to define the physiological role of CD36 in both native LDL and oxLDL metabolism in mice. METHODS AND RESULTS: Clearance studies of labeled LDL...

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Identifiers

PMID: 18436808
DOI: 10.1161/atvbaha.107.161653

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